-
Genetic Insights Into Lipid Traits and Lipid-Modifying Drug Targets in Pregnancy Complications: A Two-Sample Mendelian Randomization Study
31 Jan 2025 06:09 GMT
… controlled trial (RCT) found that pravastatin treatment for … GRAMplusC4D).33
For drug target genes significantly … modifying medications, including statins, fenofibrate, evinacumab, mipomersen, and anacetrapib, … in how different doctors or healthcare institutions …
-
Exploring the Active Compounds of Traditional Mongolian Medicine Baolier Capsule (BLEC) in Patients with Coronary Artery Disease (CAD) Based on Network Pharmacology Analysis, Molecular Docking and Experimental Validation
14 Feb 2023 01:57 GMT
… high-dose statin therapy, new lipid-lowering drugs such as … Mongolian medicine with proven clinical application for treatment of … were purchased from Nanjing Jiancheng Biotech Co., Ltd (Nanjing, … et al. Effects of anacetrapib in patients with atherosclerotic …
-
NewAmsterdam Pharma Announces Publication in Nature Medicine Discussing Clinical Potential of Obicetrapib
11 Aug 2022 20:29 GMT
… Statin Therapy (ROSE) clinical trial in the peer-reviewed journal, Nature Medicine … compared to placebo, treatment with obicetrapib led to … CETP inhibition observed with anacetrapib and evacetrapib. A … ’s ongoing clinical trials, particularly as they …
-
Can A New Cholesterol Drug Restore Merck’s Prominence In Heart Drugs?
01 Feb 2022 14:23 GMT
… the practice of medicine. Before the availability of statins, no one … REVEAL, a combination of anacetrapib and atorvastatin was shown to … FDA in 2015. However, despite the extraordinary efficacy of these drugs … . After all, taking a pill once-a-day is far …
-
This Is A Heart Drug That The World Doesn’t Need
27 Aug 2020 13:28 GMT
… fact, in early clinical trials, these drugs totally remodeled a heart patient … anacetrapib/atorvastatin vs. atorvastatin and demonstrated that the CETPi/statin … billion 30,000 patient outcomes trial. The FDA has required other companies …
-
Cardiovascular Drugs Market to be worth US$ 91.0 Billion by 2025, Says TMR
20 Aug 2019 12:30 GMT
… through counselling and medicines as per their condition … anacetrapib by Merck, and a new LDL lowering drug … company lost its hyperlipidemia treatment drug patent in early 2016 … FDA gave its approval to Watson Pharmaceuticals Inc. to launch a generic drug …
-
Obesity negates beneficial drug effects
09 Nov 2018 15:29 GMT
… ; cholesterol HDL. Outcomes from clinical trials of CETP inhibitors, however, have … participants in the CETP inhibitor trials were obese, Lin Zhu, MD … , they studied the effects of anacetrapib, a CETP inhibitor, in transgenic …
-
Pharma Failures Actually Advance Medicine
17 Oct 2018 10:09 GMT
… , one doesn’t enter pharmaceutical R&D if he … experimental medicines that enter human trials actually results in an FDA approval … LDL-cholesterol on top of statins. Some even dreamed that … to market. Merck’s entrant, anacetrapib, got the furthest. Merck …
-
Medicines Co. Sells Infectious Disease Drugs, Focusing on PCSK9
29 Nov 2017 17:43 GMT
… by Parsippany, NJ-based Medicines Co. (NASDAQ: MDCO) … trial along with partner Alnylam Pharmaceuticals (NASDAQ: ALNY). The drug … FDA-approved drugs Melinta (NASDAQ: MLNT) is buying are Vabomere, a treatment … . Merck said the anacetrapib trial met its main goal …
-
Merck scraps disappointing experimental cholesterol drug
30 Oct 2017 12:30 GMT
… closely watched experimental cholesterol medicine after mediocre test results. … its drug, a so-called CETP inhibitor called anacetrapib, long … August it disclosed the pill only cut those risks … part because cheap, genetic statin drugs lower cholesterol well for …