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CLC3 Boosts Lysosomal Function, Drives Cisplatin Resistance
13 Dec 2025 09:03 GMT
… pervasive forms of gynecologic cancers.
Cisplatin remains a frontline chemotherapeutic agent widely used … more efficient breakdown of cisplatin, reducing intracellular drug accumulation and leading to …
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Hypoxia-Induced Autophagy Drives Lung Cancer Drug Resistance
12 Dec 2025 03:16 GMT
… cisplatin upon activation of this axis.
Importantly, pharmacological … precision medicine strategies … cisplatin or other chemotherapeutics. Such strategies might rescue drug … cancerhypoxia-induced autophagyhypoxic microenvironment influencelung cancer drug …
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NanOlogy Unveils Drug Development Program for Rare Pediatric Brainstem Tumor
12 Dec 2025 16:05 GMT
… Unfortunately, current systemically administered cisplatin formulations are associated with … ;s innovative LSAM-Cisplatin investigational drug designed for intratumoral administration … ovarian, prostate, and dermal cancers. Feasibility of the Purcision™ …
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The Role of Pyroptosis in Colorectal Cancer: From Mechanisms to Therapeutic Opportunities
11 Dec 2025 21:49 GMT
… in Colorectal Cancer
Accompanied by medical advances, GSDMD … of colorectal cancer cells to chemotherapeutic drugs. Patients with … oxaliplatin; CDDP,cisplatin; CRC, colorectal cancer; CVB3, coxsackievirus … signalling pathway. Front Pharmacol. 2022;13:952587. …
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U.S. Food and Drug Administration (FDA) Grants Priority Review to Bristol Myers Squibb's Application for Opdivo® (nivolumab) Plus Chemotherapy Combination for Classical Hodgkin Lymphoma
11 Dec 2025 18:37 GMT
… (nivolumab), in combination with cisplatin and gemcitabine, is indicated … in combination with chemotherapy; these included pneumonitis … ’s cancer research is to deliver medicines that … development and commercialization of pharmaceutical products. All statements …
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Evodiamine Targets Genes in Cisplatin-Resistant Lung Cancer
11 Dec 2025 08:45 GMT
… -small cell lung cancer (NSCLC). Cisplatin, a platinum-based chemotherapy drug, is a cornerstone … critical questions surrounding optimal dosing, pharmacokinetics, and potential synergy with other …
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New Discovery May Improve Ovarian Cancer Treatment
11 Dec 2025 02:56 GMT
… cancer starts with a platinum-based chemotherapy, such as carboplatin or cisplatin. This chemotherapy … is often given with another drug …
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Fennec Pharmaceuticals Announces Investigator-Sponsored Trial to Be Conducted by City of Hope in Metastatic Testicular Germ Cell Tumors
09 Dec 2025 12:00 GMT
… M.S., chief medical officer of Fennec Pharmaceuticals. “With cancer rates rising, especially … of PEDMARK® to Cisplatin Chemotherapy for Reducing Drug-Induced Ear Damage in … specialty pharmaceutical company committed to the fight against ototoxicity in cancer …
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<![CDATA[How Will ADCs Influence the Treatment Landscape in SCLC?]]>
11 Dec 2025 19:52 GMT
… Cancer Institute, and assistant professor of medicine at Harvard Medical … durvalumab plus etoposide and cisplatin or carboplatin.4 … discussion, but how [antibody-drug conjugates (ADCs)] have … outcomes by prior concurrent chemoradiotherapy (cCRT) regimen and …
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<![CDATA[Fed Ghali, MD on key unanswered questions with perioperative EV/pembro ]]>
11 Dec 2025 17:18 GMT
… in patients with cisplatin-ineligible muscle-invasive bladder cancer (MIBC).1
In … plus pembrolizumab (EVP) in bladder cancer. Specifically, Ghali considers the potential … School of Medicine and a urologic oncologist at Yale Cancer Center in …
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