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Dr Watson on the Use of Oncogene Analysis to Determine Clinically Relevant HER2, KRAS and MET Copy-Number Gain in NSCLC
21 Dec 2024 00:28 GMT
… relevant thresholds for HER2, KRAS, and MET gene copy … CNG) in non–small cell lung cancer (NSCLC).
Watson and colleagues retrospectively … between CNG of HER2, KRAS, and MET oncogenes and … coexisted with highly amplified HER2, KRAS, and MET genes, considering …
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Verastem Oncology Provides a Clinical Update for RAMP 203 Trial in Advanced KRAS G12C Mutant Non-Small Cell Lung Cancer
18 Dec 2024 12:41 GMT
… in treating KRAS G12C mutant non-small cell lung cancer.”
RAMP 203 … avutometinib plus sotorasib in KRAS G12C mutant NSCLC models, … been previously treated with a KRAS G12C inhibitor (NCT05074810). RAMP … in adults with recurrent KRAS mutant LGSOC who received …
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Glutathione <em>S</em>-transferase inhibitor displays robust efficacy in lung cancer models
17 Dec 2024 17:06 GMT
Glutathione S-transferase (GSTP) is an enzyme involved in the detoxification of several xenobiotics such as tobacco carcinogens or cisplatin drugs and is overexpressed in KRAS-mutant lung, colon and pancreatic cancer, among others. The upregulation of GSTP …
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Adagrasib in KRYSTAL-12 has Not Broken the KRAS G12C Enigma Code of the Unspoken 6-Month PFS Barrier in NSCLC
17 Dec 2024 15:04 GMT
… in non-small cell lung cancer patients: correlation with … treated non-small-cell lung cancer with KRASG12C mutation: … advanced NSCLC with KRAS G12C mutation. Lung Cancer. 2024;196:107921 … in KRAS G12C mutation positive non-small cell lung cancer. Lung Cancer. …
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PESG Releases Market Update: Silexion Therapeutics Advances KRAS-Targeting Therapies with New Collaboration As Industry Demand for Precision Oncology Solutions Rises
17 Dec 2024 14:40 GMT
… for groundbreaking therapies.
KRAS Mutations: A Major … in colorectal and lung cancers, KRAS mutations drive aggressive … in colorectal and lung cancers opens substantial market opportunities … -targeted treatments.
The KRAS inhibitor market, currently …
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Bubble Ticket Trip: Exploring the Mechanism of miRNA Sorting into Exosomes and Maintaining the Stability of Tumor Microenvironment
20 Dec 2024 18:16 GMT
… migration, and invasion of lung cancer cells.36 Exosome-derived miR … proliferation and migration for lung cancer cells in the blood … miRNA in exosomes. The KRAS-MEK signaling pathway regulates … cell-derived exosomes promote lung cancer progression via miRNA-21- …
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Bioatla, Inc. Announces Registered Direct Offering To Advance Two Mid-Stage Clinical Programs To Key Inflection Points
20 Dec 2024 14:18 GMT
… data in mutated KRAS (mKRAS) non-small cell lung cancer (NSCLC) (expected readout …
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BioAtla, Inc. Announces Registered Direct Offering to Advance Two Mid-Stage Clinical Programs to Key Inflection Points
20 Dec 2024 14:00 GMT
… data in mutated KRAS (mKRAS) non-small cell lung cancer (NSCLC) (expected readout …
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Break Through Cancer and Revolution Medicines Collaborate to Study Biomarkers for RAS(ON) Inhibitor in Pancreatic Cancer
19 Dec 2024 16:45 GMT
… cancer, non-small cell lung cancer and colorectal cancer.
The … org.
About the Conquering KRAS in Pancreatic Cancer TeamLab … Bringing together experts in KRAS biology, PDAC research, and … information about the Conquering KRAS in Pancreatic Cancer program …
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Identification and Validation of Ferroptosis Related Genes in Ischemic Stroke and Its Effect on the Peripheral Immune Landscape
19 Dec 2024 11:55 GMT
… , the expression levels of FTH1, KRAS, ATF3, MUC1, and HCAR1 are … ’s interesting to note that lung cancer stem cell-like cells (CSLC … SOX2 confers ferroptosis resistance in lung cancer via upregulation of SLC7A11. Cancer …
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