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Monlunabant Misses Primary Endpoint in Phase 2 Diabetic Kidney Disease Trial
05 Feb 2025 16:58 GMT
… an update on its pharmacologic pipeline for obesity … for monlunabant. Trial findings indicated the drug was safe and … -conditions/diabetic-nephropathy/diagnosis-treatment/;drc-20354562
… .6892
Brooks A. FDA Approves Semaglutide (Ozempic) for …
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Mineralys Therapeutics Completes Enrollment in Explore-CKD Phase 2 Trial of Lorundrostat for the Treatment of Hypertension in Subjects with Stage 2 to 3b CKD and Albuminuria
04 Feb 2025 13:00 GMT
… novel treatment modality. Poorly controlled hypertension, and hypertensive nephropathy, … with currently available medications. Dysregulated aldosterone levels … States Food and Drug Administration (FDA); the Company’ … with Mitsubishi Tanabe Pharma to provide us …
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How novel antibody felzartamab impacts IgA nephropathy?
03 Feb 2025 22:04 GMT
… surface. A recent Phase 2 trial revealed that felzartamab, an investigational … recovered within 4 months off-treatment, suggesting the preservation of components … + antibody secreting cells in IgA nephropathy pathogenesis,” said corresponding author Millie …
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Puerarin Ameliorates the Ferroptosis in Diabetic Liver Injure Through the JAK2/STAT3 Pathway Inhibition Based on Network Pharmacology and Experimental Validation
01 Feb 2025 16:25 GMT
… and more effective drugs for the treatment of DLI and … targets for Puerarin to treat disease by regulating ferroptosis. … selected as the experimental drug concentrations.
Figure 5 … signaling pathway in diabetic nephropathy. Front Pharmacol. 2021;12:681424. …
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Nephrology Month in Review: January 2025
05 Feb 2025 01:38 GMT
… a year of progress in treatment, equitable care, and enhanced … as key insights into IgA nephropathy (IgAN) incidence, prevalence, … the US Food and Drug Administration approved Novo Nordisk’s … 3b FLOW kidney outcomes trial, which demonstrated semaglutide’s …
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Top biotech deals of January 2025
06 Feb 2025 17:18 GMT
… . Food and Drug Administration (FDA)-approved treatment for depression in … this class of drugs to treat cancer.
Chinese biotech … , Japanese company Chugai Pharmaceutical and Swiss company Araris … candidate is designed to treat IgA nephropathy – a chronic kidney …
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AstraZeneca Axes Two Alexion Assets as Q4 Earnings Exceed Expectations
06 Feb 2025 15:54 GMT
… small molecule drug, was culled from the pharma’s development … lupus nephritis or immunoglobulin A nephropathy, according to AstraZeneca’s … in 2025, with the pharma working toward expansion into … kidney injury and IgA nephropathy, according to a company …
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Gut Microecological Prescription: A Novel Approach to Regulating Intestinal Micro-Ecological Balance
05 Feb 2025 07:15 GMT
… and viral infections, medications (prokinetic drugs) that alter … treatment of recurrent and refractory clostridium difficile infection. Aliment Pharmacol … controlled phase 2 trial. Nat Med. 2021;27 … intervention on diabetic nephropathy: an umbrella …
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Application of Nanomaterial-Mediated Ferroptosis Regulation in Kidney Disease
05 Feb 2025 07:15 GMT
… (C) Weight change after medication. (D) SCR and … nephropathy through regulating oxidative stress and ferroptosis: a precise treatment … M, et al. Pharmacological inhibition of cystine–glutamate … Low dimensional nanomaterials for treating acute kidney injury. …
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Relationship Between Serum HMGB1 and RAGE Levels and Restenosis in Type 2 Diabetes Mellitus Patients Complicated With Lower Extremity Vascular Disease: A Retrospective Study
01 Feb 2025 16:25 GMT
… risk factor for diabetic nephropathy progression.11 Previous … medical treatment, surgical treatment, and interventional surgery. Compared to pharmacological therapy … Upreti P, et al. Drug-eluting stent vs. balloon … perspectives. Eur J Med Res. 2023;28( …