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IPBM 2025 highlights emerging precision medicine and clinical advances in pancreatic cancer
07 Apr 2025 03:05 GMT
… in applying precision medicine to pancreatic … trials.”
She also highlighted the practical challenges of drug development. “De novo drug … regimen (nanoliposomal irinotecan, oxaliplatin, 5-fluorouracil, and … effectively in clinical treatment.”
Park also …
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FDA Grants HLX22 Orphan Drug Designation for Gastric Cancer
06 Apr 2025 16:56 GMT
… and Drug Administration (FDA) has granted orphan drug designation … for HLX22, an anti-HER2 monoclonal antibody for the treatment … trastuzumab), capecitabine and oxaliplatin improved progression-free … phase 3 clinical trials, according to the …
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CRC Yields Most Prevalent Data at Recent GI Meeting
04 Apr 2025 23:01 GMT
… Hopkins School of Medicine, discussed presentations from … as a first-line treatment for microsatellite instability … [fluorouracil, leucovorin, and oxaliplatin (FOLFOX)] for patients … www.fda.gov/drugs/;resources-information-approved-drugs/fda-grants …
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HIPEC/CRS Confers No Benefit, Adds Risk in Colorectal Peritoneal Metastases
04 Apr 2025 02:47 GMT
… the phase 3 PRODIGE-7 trial (NCT00769405), which evaluated the …
Transcript:
When choosing a treatment option, there always has to … [CRS] with HIPEC [plus] oxaliplatin. They reported, although non-significant … , open-label, phase 3 trial. Lancet Oncol. 2021;22(2 …
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Development of a Nomogram Integrating Modified Inflammation-Based Indexes for Predicting Overall Survival in Pancreatic Cancer: A Retrospective Study
07 Apr 2025 17:09 GMT
… diagnoses, the definitive treatment plan was typically … 2) availability of complete medical records. Conversely, exclusion … PS 0–1), FOLFIRINOX (oxaliplatin, irinotecan, calcium folinate, fluorouracil … increased likelihood of drug-resistant clones within …
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ctDNA-Guided Approaches Reveal Effective Adjuvant Agents in MRD+ CRC
07 Apr 2025 12:37 GMT
… inflammatory drug celecoxib (Celebrex) plus fluorouracil, leucovorin, and oxaliplatin ( … well as the medical director of the Cancer … the CIRCULATE-Japan GALAXY trial [UMIN000039205], [the observational … with] or forego treatment.
What studies are helping …
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Polyallylamine Hydrochloride-Modified Bovine Serum Albumin Nanoparticles Loaded with α-Solanine for Chemotherapy of Pancreatic Cancer
07 Apr 2025 09:01 GMT
… oxaliplatin) has become the gold standard for pancreatic cancer treatment, … 900 nanotechnology-based anticancer drugs for clinical trials, yet only a … for Local Antitumor Therapy. Pharmaceutics. 2022;14:2028. doi … . Artif Cells Nanomed Biotechnol. 2021;49(1):136 …
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Development of a Nomogram for Prognostic Prediction of Large Hepatocellular Carcinoma With HBV After TACE Combined Conversion Therapy
07 Apr 2025 09:01 GMT
… Yale University School of Medicine, New Haven, Conn). … studies, ideally clinical trials, enrolling individuals with … hepatic arterial infusion of oxaliplatin, fluorouracil, and leucovorin … locoregional treatments and immunotherapy for the treatment of …
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IO Research Pays Off in MSI-H/dMMR CRC but Misses the Mark in MSS/pMMR Disease
06 Apr 2025 16:29 GMT
… ongoing phase 3 MOUNTAINEER-03 trial (NCT05253651) is evaluating the … 5-fluorouracil, leucovorin, and oxaliplatin) in in the first-line … and section chief for Medical Oncology in the Department … approved by the FDA [in 2023 for the treatment of patients …
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Unveiling the Novel Anti - Tumor Potential of Digitonin, a Steroidal Saponin, in Gastric Cancer: A Network Pharmacology and Experimental Validation Study
05 Apr 2025 08:44 GMT
… branch of integrative medicine, traditional Chinese medicine (TCM) … experiments confirmed that Digitonin treatment significantly downregulated HSP90AA1 … on platinum-based (eg, oxaliplatin) and fluoropyrimidine (eg, … cancer. Comput Struct Biotechnol J. 2022;20 …