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P53 Is Both Your Genome’s Guardian and Weakness Against Cancer – Scientists Are Trying to Repair or Replace It When It Goes Awry
05 Apr 2025 08:48 GMT
… . One such mechanism involves a protein called p53. Often dubbed the “guardian … often happens when the gene that encodes for p53 is mutated or … to bind DNA and regulate genes. Drugs like PRIMA-1 and …
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RNA Sequencing Identifies Novel Signaling Pathways and Potential Drug Target Genes Induced by FOSL1 in Glioma Progression and Stemness
05 Apr 2025 08:44 GMT
… performed on different gene sets, allowing genes with similar … both mRNA and protein levels. This gene has been … dependent cotranslational protein targeting to membrane, cotranslational protein targeting … cancer cells by the P53 signaling pathway. Oncol Rep …
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New study reveals protector protein that supports hair regrowth in adults
29 Mar 2025 12:58 GMT
… require a powerful protector protein called MCL-1 to … P53 protein essential for regulating cell death. However, deletion of a P53 gene …
New study reveals protector protein that supports hair regrowth … 2025-03-reveals-protector-protein-hair-regrowth.html
This …
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S100 Protein Family in Lung Cancer: an Updated Narrative Review
27 Mar 2025 13:21 GMT
… correlated with positive P53 staining and considered … Cancer
In general, the S100 protein family is … developing medicines against S100 proteins, requires addressing several … Clinicopathological significance of S100 protein expression in cholangiocarcinoma. …
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Stopping hair loss may be as easy as boosting this "bodyguard" protein
27 Mar 2025 07:25 GMT
… a certain "bodyguard" protein. This protein, MCL-1, is a … stress, aging, cancer drugs or genetics, HSFCs are left vulnerable and … of scientists found that the protein TGF-beta played a role … of the MCL-1 protein. And by blocking P53 or boosting MCL …
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Unraveling the Prognostic Significance of BRCA1-Associated Protein 1 (BAP1) Expression in Advanced and Castrate-Resistant Prostate Cancer.
27 Mar 2025 07:21 GMT
… in Western societies. BRCA1-associated protein 1 (BAP1) expression significance has … (PTEN) loss or ETS-related gene (ERG)-positive cases, resulting in … PTEN (moderate or high expression), p53 (wild type), and androgen receptor …
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A Chemotherapy Response-Related Gene Signature and DNAJC8 as Key Mediators of Hepatocellular Carcinoma Progression and Drug Resistance
19 Mar 2025 21:46 GMT
… Differentially Expressed Gene Analysis
Differential gene expression was … gene 1) + (coefficient of gene 2 × expression level of gene 2) + … + (coefficient of gene … MUC16, 17.9%), Tumor Protein P53 (TP53, 16.6%), … in the p53 gene. The wild-type p53 gene, located …
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Ezh2 Delays Activation of Differentiation Genes During Normal Cerebellar Granule Neuron Development and in Medulloblastoma
18 Mar 2025 22:45 GMT
… , patients with P53 mutations often have … confidence differentiation genes. Briefly, genes are segregated … genes, highest P0-7 proliferation genes, highest at E15 embryonic genes); 5 excluded genes … genes including cell adhesion proteins and another 28 proteins …
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DNA Repair Protein Suppresses "Zombie" Cells, Reducing Age-Related Inflammation
17 Mar 2025 11:27 GMT
… ability of a DNA repair protein to suppress SASP, which … that DNA fixer tumor protein p53 suppressed SASP and one … expression of the gene carrying the blueprint for p53.
“Altogether, we … design a treatment that targets p53 to promote healthier aging.” …
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Gene Editing: An Effective Tool for the Future Treatment of Kidney Disease
17 Mar 2025 08:29 GMT
… target genes to alter genetic traits and generate new phenotypes … precision treatment.
Gene Editing Overview
Gene editing technology enables … fibroblasts with inactivated P53 gene to detect a … X mental retardation protein (FMRP) gene in induced pluripotent …