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A new potential strategy for cutaneous squamous cell carcinoma treatment by generating serum-based antibodies from tumor-exposed mice
15 Oct 2024 22:34 GMT
… as foreign objects and generate corresponding antibodies in a … p53, Bcl-xL, NF-κB, and Bax, four mCSCC-associated proteins … an immune response and generating antibodies in a healthy individual … for mCSCC treatment by generating serum-based antibodies from …
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Clasp Therapeutics to Present Preclinical Data Evaluating Novel T Cell Engager Targeting p53 Mutant Solid Tumors
04 Oct 2024 13:08 GMT
… to immuno-oncology using next-generation T cell engagers (TCEs), … a TCE targeting a common p53 mutation, at the 2024 Annual … T cell engager targeting a p53 R175H mutant peptide presented by … in immuno-oncology through next-generation T cell engagers (TCEs) …
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Molecular Subtypes Defined by Cuproptosis-Associated Genes, Prognostic Model Development, and Tumor Immune Microenvironment Characterization in Adrenocortical Carcinoma
03 Oct 2024 06:59 GMT
… patterns. We identified prognostic genes associated with cuproptosis by … gene clusters labeled as gene cluster A, gene cluster B, and gene …
Validation of Protein Expression Levels of Risk Genes in ACC … Gemma C, et al. p53 controls expression of the DNA …
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Comprehensive Analysis of the Significance of Breast Cancer Gene 1 (BRCA-1) in Bladder Cancer
30 Sep 2024 07:00 GMT
… associated gene-gene interaction network was generated using the GeneMANIA database. … biological functions through gene-gene interaction and GSEA … the tumor suppressor gene BRCA1’s protein product.37– … study of p53-pathway related prognostic gene signature set …
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Consensus Clustering Analysis Identifies Ferroptosis-Related Patient Clusters and Predictive Signature Construction Based on Ferroptosis-Related Genes in Ischemic Cardiomyopathy
30 Sep 2024 07:00 GMT
… Function (CDF) curve generated by ConsensusClusterPlus, aiming … this phenomenon.
Differential Gene Expression and Enrichment Analysis … the interaction between protein coding transcripts and … polyamine metabolism with p53-mediated ferroptotic responses. …
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The Mechanism of APOBEC3B in Hepatitis B Virus Infection and HBV Related Hepatocellular Carcinoma Progression, Therapeutic and Prognostic Potential
17 Oct 2024 07:54 GMT
… pathways via its oncoviral gene proteins (HBx and Pre-S … as a nucleocytoplasmic shuttling protein.53 Consequently, A3B reduces … somatic mutations in genes such as P53 and PIK3CA.32 … oligomerization domain-like receptor protein 3, apoptosis-associated speck …
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Comprehensive Analysis of Angiogenesis and Ferroptosis Genes for Predicting the Survival Outcome and Immunotherapy Response of Hepatocellular Carcinoma
28 Sep 2024 14:16 GMT
… E). Six overlapping genes among these genes were used to … that the extensively mutated p53 gene in tumors is strongly … D. The tumor suppressor protein p53 and the ferroptosis network. … the progestagen-associated endometrial protein gene in human melanoma. J …
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Adventism & Catholicism in a Changing World: What can we learn from each other?
17 Oct 2024 03:32 GMT
… criticized by Protestants in general, and by Adventists in … of constituency meetings and general conferences, while for Catholics … Time.” https://genealogiesofmodernity.org/journal/2020 … ., 32, no. 3 (Summer 2004), p. 53. ↑
Ibid., p. 50. ↑
C …
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PPI-hotspotID for detecting protein–protein interaction hot spots from the free protein structure
16 Sep 2024 19:35 GMT
… structures generally predict residues that make multiple contacts across the protein–protein … with PIDD (p53-induced death domain-containing protein). Based on … -Multimer and future improved protein–protein complex prediction methods require knowledge …
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Polymorphisms in miRNA Genes Targeting the AMPK Signaling Pathway are Associated with Cervical Cancer Susceptibility in a Han Chinese Population
16 Sep 2024 09:48 GMT
… .
miRNA Selection, Target Gene Prediction and Signal Pathway … ) E1 protein regulates the expression of cellular genes involved in … , haplotype construction, and genetic association at polymorphism loci. … the GADD45B-MAP2K3-p38-p53 feedback loop. Cell Death …