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Swimming Individuals: Monument's Kline, Iusco win two events each as Berkshire County swimmers eye postseason
02 Feb 2025 06:52 GMT
… .32. Kearns also helped the Generals to a third-place finish … .67.
100 Free — 1. Kearns (P) 53.76; 2. Schroder (NL) 54 …
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ADC Anetumab Ravtansine Does Not Improve PFS vs Paclitaxel in High-Grade Serous Ovarian Cancer
30 Jan 2025 19:32 GMT
… .29 [0.58-2.87]; P = .53).
Of the 15 patients in … enhance ADC activity with new generations and potential combinations.”
References
Alqaisi …
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Intervening Non-Small-Cell Lung Cancer Progression by Cell Membrane Coated Platycodin D via Regulating Hsa-miR-1246/FUT9/GSK3β Pathway
06 Feb 2025 08:13 GMT
… #47;β-catenin signaling pathway, generally inhibiting tumor metastasis. Conversely, … list of core genes, we conducted gene ontology and KEGG … , under the regulation of p53, inhibited tumor growth in … target a range of genes or proteins, their biological roles …
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Targeting SLC7A11-mediated cysteine metabolism for the treatment of trastuzumab resistant HER2 positive breast cancer
05 Feb 2025 20:06 GMT
… dysregulation modulates key genes transcription associated with … certain metabolism-related protein, epigenetic modification or … genes in JIMT1 are highlighted in blue. (G) Expression of essential proteins … stress and activate p53 upregulated modulator of …
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Application of Nanomaterial-Mediated Ferroptosis Regulation in Kidney Disease
05 Feb 2025 07:15 GMT
… of morphology, biochemistry and genetics, this form of … , the tumor suppressor protein p53 can modulate cystine uptake … of reactions that generate iron-dependent lipid peroxidation … , synthesized from lipids, proteins, polysaccharides, and functional polymers …
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HLRS: Simulation Supports Search for Personalized Cancer Treatments
03 Feb 2025 18:56 GMT
… investigate hard-to-treat genetic mutations linked to aggressive … occurs in p53, however, an alteration in its genetic code … to mutations that inactivate the p53 protein.
One approach in cancer … Although the static image generated using X-ray crystallography …
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Study on the Regulated Cell Death of Hypertrophic H9c2 Cells Induced by Au:Ag Nanoparticles
03 Feb 2025 12:14 GMT
… increase in mitochondrial superoxide generation on diverse cells, … expression of genes associated with intrinsic apoptosis (p53, caspase- … Ag bimetallic nanoparticles using protein extracts of deinococcus … reactive oxygen species generation with regard to …
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Prostate Cancer Bone Metastasis: Molecular Mechanisms of Tumor and Bone Microenvironment
01 Feb 2025 10:18 GMT
… proteins by suppressing the promoter activity of genes … through multiple mechanisms: generating reactive oxygen species … , migration, extracellular matrix protein degradation, and promoting angiogenesis … of Wild-type p53 Facilitates Bone Metastatic Function …
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Highly Stable Antitumor Silver-Lipid Nanoparticles Optimized for Targeted Therapy
01 Feb 2025 10:18 GMT
… -1 and its downstream gene vascular endothelial growth factor … of the pH dependent generation of hydroxyl radicals and … Silver nanoparticles defeat p53-positive and p53-negative osteosarcoma cells … factor-1 and target genes: insight into the cytotoxicity …
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Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth
01 Feb 2025 00:09 GMT
… DNA lesions, highly transcribed genes, or tightly bound protein complexes, causing what … recruits the Ser/Thr protein kinase ATR (Zou and … also signaled by two other protein kinases, ATM and DNA- … and promoting the loss of p53 Halazonetis et al., 2008; …