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Observational Data Challenge p53 Expression as a Surrogate Marker for TP53 Mutations in High-Risk Endometrial Cancer
31 Jan 2025 00:21 GMT
… but had aberrant or abnormal p53 protein expression [n = 13 … and concordance of aberrant p53 protein expression and TP53 … TP53 mutational status and p53 protein expression. Patients with … frequency of TP53 protein expression and gene sequence in mismatch …
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Systematic Analysis of E3 Ligase-Related Genes Identified UBE2L3 as a Prognostic Biomarker Associated With Drug Resistance in Acute Myeloid Leukemia
29 Jan 2025 16:06 GMT
… ligase-related genes searched in the GeneCards database … Venn diagram showing differential genes screened from GeneCards data, UniProt database … ubiquitin ligase-related genes, Gene Ontology (GO) and … the tumor suppressor protein p53 by the ubiquitin- …
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Alteration in Oxidative Stress Enzymes and Proteins by Datura metel Stramonium Hydroethanolic Root Extract Promotes Hippocampus and Cerebral Cortex Neurons Damage in Adult Sprague Dawley Rats
25 Jan 2025 15:11 GMT
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Expression of Neurofilament Protein and Neuron Specific … expression of neurofilament proteins. Neurofilament proteins were moderately expressed … moderate expression of neurofilament proteins, whereas high doses … by gfap and p53 protein alterations in rats …
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Adipokines in Breast Cancer: Decoding Genetic and Proteomic Mechanisms Underlying Migration, Invasion, and Proliferation
25 Jan 2025 09:05 GMT
… p53 and upregulation of the anti-apoptotic gene … which generated fold values representing the gene expression difference … differences between groups.
Protein Expression
The conditioned … -gamma induced protein (IP)-10, Monocyte chemoattractant protein (MCP) …
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Comprehensive Analysis of Programmed Cell Death-Related Genes in Diagnosis and Synovitis During Osteoarthritis Development: Based on Bulk and Single-Cell RNA Sequencing Data
17 Jan 2025 14:00 GMT
… < 0.05.
Protein-Protein Interaction Networks (PPI) and … pathway, apoptosis, and P53 pathway was significantly upregulated … al. STRING v11: protein-protein association networks with increased … et al. Unfolded protein response gene GADD34 is overexpressed in …
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Identification and Characterization of Genes Associated with Intestinal Ischemia-Reperfusion Injury and Oxidative Stress: A Bioinformatics and Experimental Approach Integrating High-Throughput Sequencing, Machine Learning, and Validation
16 Jan 2025 09:05 GMT
… to construct a protein-protein interaction network. Subsequently … to construct a protein-protein interaction network, and … PINK1 and p53, resulting in reduced p53 acetylation, … expressed genes; SPF, specific pathogen-free; PPI, protein-protein interaction; …
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Effects of Tp53 Gene Mutations on the Survival of Non-Small Cell Lung Cancer (NSCLC); A Short Review
15 Jan 2025 11:59 GMT
… accrual of genetic modifications in genes governing cell proliferation … 1 Genes and proteins are regulated in response to p53 activation … mechanism of stimulating p53 protein activity. In tissues … analysis revealed that p53 gene mutations were significantly …
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Nuclear Speckles Identified as Key Hubs for Gene Expression Regulation
11 Jan 2025 02:20 GMT
… organization within cells impacts gene expression and could open … well-known tumor suppressor proteins, such as p53, via its long … “These proteins are known to recruit their target genes to nuclear … and their implications in gene regulation and cancer.”
This …
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Frontier Medicines Announces FMC-220, the First Covalent p53 Y220C Activator Development Candidate, with Best-in-Class Potential
09 Jan 2025 13:00 GMT
… . The Y220C mutation destabilizes the p53 protein, impairing its tumor-suppressive functions … medicines to transform treatment for genetically-defined patient populations, starting with … hard-to-treat disease causing proteins for drug development. Today, we …
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p53 engagement is a hallmark of an unfolded protein response in the nucleus of mammalian cells
07 Jan 2025 15:09 GMT
… When stabilized, p53 protein transactivates target genes that induce cell … nuclear unfolded protein activate p53?
p53 is a … and accumulation of p53 protein promotes its nuclear … orphan proteins, especially ribosomal proteins and proteins with intrinsically …