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NOLC1 Suppresses Immuno-chemotherapy by Inhibiting p53-mediated Ferroptosis in Gastric Cancer
25 Dec 2024 00:12 GMT
… is caused by gene mutations, gene inactivation, epigenetic … levels of p53 and downstream genes of p53 (CDKN1A, … p53-responsive gene, is the master antagonist of p53 by promoting p53 … regulating p53 total protein levels, thus inhibiting p53 transcriptional …
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Oncogenic and teratogenic effects of p53Y217C, a mouse model of the human hotspot mutant p53Y220C
25 Dec 2024 00:12 GMT
… analyze protein extracts from p53+/+, p53+/-, p53+… classical p53 target genes, appeared similar in p53+/+ and p53+… intracellular distribution of the p53 protein, associated with a … effect over the wildtype p53 protein.
We next compared …
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Impeach VP Sara yourself, don’t use PhilHealth money
31 Dec 2024 17:56 GMT
… and professionals, religious leaders, retired generals, former Cabinet members, academics and … ’t learned from the retired generals’ outrage when pensions nearly were … in 2025. Included is the P53-billion automatic sin tax share …
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Critical Recent NCCN Guideline Updates Affect Dozens of Malignancies
31 Dec 2024 16:03 GMT
… that have an NTRK gene fusion and fam-trastuzumab … therapies, particularly the second-generation covalent BTK inhibitors like acalabrutinib … might consider preferring a cheap generic option to the expensive … , how much expression of P53 do you need by IHC …
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Carrier-Free, Hyaluronic Acid-Modified Self-Assembled Doxorubicin, and Chlorin e6 Nanoparticles Enhance Combined Chemo- and Photodynamic Therapy in vivo
31 Dec 2024 04:29 GMT
… binding of NPs to plasma proteins in the blood, and … ATP-binding cassette pumps employing “Generally Recognized As Safe” (GRAS … for photodynamic therapy: ROS generation, mechanism and detection methods. … Chen GB. Nuclear-targeted p53 and DOX co-delivery of …
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Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth
30 Dec 2024 17:51 GMT
… , highly transcribed genes or tightly bound protein complexes, causing … by inhibiting AKT, a protein kinase involved in cell … chemotherapy, presumably by inhibiting p53-dependent apoptosis (Jiang et … from RCSB Protein Data Bank. The proteins and compound …
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Digitalization may boost telco growth in 2025
30 Dec 2024 18:21 GMT
… -speed internet and 5G (fifth generation)-enabled solutions to more sophisticated … that rose 1.98% to P53.36 billion from a year …
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Traditional Uses, Phytochemistry, Pharmacology and Toxicology of Ruta graveolens L.: A Critical Review and Future Perspectives
30 Dec 2024 16:02 GMT
… R. graveolens..
Antimicrobial Effects
Generally, R. graveolens shows inhibitory … (ERK1/2) and protein kinase B (AKT), resulting … R. graveolens induced the P53 pathway and DNA damage … Laminaria japonica) in rats. General Pharmacology: The Vascular System, …
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New Posttranslational Modification Lactylation Brings New Inspiration for the Treatment of Rheumatoid Arthritis
30 Dec 2024 09:36 GMT
… can also regulate fibrosis genes such as PDGFA, … 1 (PER1) and tumour protein P53 (TP53) mRNAs and … monophosphate response element binding protein (CBP)-dependent mechanism … protein antibodies; anti-CarP, anti-carbamylated protein; FOXP3, forkhead box protein …
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EIF4A3 Enhances the Proliferation and Cell Cycle Progression of Keloid Fibroblasts by Inducing the hsa_circ_0002198 Expression
30 Dec 2024 09:35 GMT
… Subsequently, RNA/protein extraction and additional functional … B). Protein expression levels of cell cycle-regulating genes in … cell division.
CircRNA-protein interactions affect protein expression, biogenesis, … shown to induce p53 and P21 expression …