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Novel Skp1 inhibitor has potent preclinical efficacy against castration-resistant prostate cancer.
23 Apr 2025 16:17 GMT
… in preclinical models of human prostate cancer. Immunohistochemistry was employed to … cell- and patient-derived xenografts in intraosseous and subcutaneous models … is significantly increased in human prostate cancer specimens.
These results indicate …
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Reprogramming of Androgen Receptor Activity in Castration-resistant Prostate Cancer is Shaped by Truncated Variants.
15 Apr 2025 13:10 GMT
… selective pressure of treatment, prostate cancer cells express constitutively active androgen … cohort of patient-derived xenografts of metastatic prostate cancer with diverse AR … additional models of AR-driven prostate cancer.
The emergence of ARv567es …
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Targeting AXL Inhibits the Growth and Metastasis of Prostate Cancer in Bone - Beyond the Abstract
11 Apr 2025 01:08 GMT
… -resistant prostate cancer and neuroendocrine prostate cancer.2 … derived xenograft (PDX) models of prostate cancer … -resistant prostate cancer and neuroendocrine prostate cancer. This … castration-resistant prostate cancers suggesting therapeutic targets …
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Heterogeneous Responses to High-Dose Testosterone in Castration-Resistant Prostate Cancer Tumors with Mixed Rb-Proficient and Rb-Deficient Cells.
27 Mar 2025 07:21 GMT
… remains a cornerstone in managing prostate cancer. However, its recurrence often leads … the more aggressive castration-resistant prostate cancer (CRPC). Although second-line androgen … utilized a CRPC patient-derived xenograft model that includes both Rb …
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Small-molecule RNA therapeutics to target prostate cancer.
24 Mar 2025 14:57 GMT
… most lethal form of prostate cancer, castration-resistant prostate cancer (CRPC), we use a … tumorigenesis in patient-derived and xenograft models and prolonged survival in …
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Researchers uncover new, highly prevalent form of prostate cancer
21 Mar 2025 18:30 GMT
… also used patient-derived xenografts, a process that grows … information on 366 prostate tumours revealed this subtype … backbone of treatment for prostate cancer has been hormone-deprivation … because, essentially, all prostate cancers when they are first …
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LSD1+8a is an RNA biomarker of neuroendocrine prostate cancer.
17 Mar 2025 12:09 GMT
… aggressive subtype of prostate cancer harboring a neuronal program-neuroendocrine prostate cancer (NEPC)-but … collection of prostate cancer patient cell lines and patient-derived xenografts (PDXs), we …
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Fatty acid binding protein 5 inhibitors as novel anticancer agents against metastatic castration-resistant prostate cancer.
11 Mar 2025 10:00 GMT
Prostate cancer (PCa) is one of the … drugs for metastatic castration-resistant prostate cancer (mCRPC). However, there is … CRPC. FABP5 is overexpressed in prostate cancer cells and chaperones fatty acids … cells and PC-3 tumor xenografts. In the present work, …
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Annexin A: Cell Death, Inflammation, and Translational Medicine
26 Apr 2025 05:08 GMT
… cancer, Annexin A9 downregulation inhibits xenograft tumor growth and lung metastasis … expression and translocation in human prostate cancer cells. J Toxicol Environ Health …
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Androgen receptor non─canonical domain binding degrader for treatment of relapsed, refractory castration─resistant prostate cancer
05 Mar 2025 03:02 GMT
… on prostate cancer in Lancet that prostate cancer “tsunami … and prostate cancer advances to castration-resistant prostate cancer ( … castration-resistant prostate cancer therapeutics. Several … castration-resistant prostate cancer and intact xenograft, and …
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