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Pyrotinib-Based Therapy May Improve Survival in Patients With HER2+ Breast Cancer and Liver Metastases
25 Apr 2025 15:47 GMT
… (HER2+) advanced metastatic breast cancer (mBC) with liver … compared with the lapatinib (Tykerb; GSK)-capecitabine regimen. … positive liver metastatic advanced breast cancer. Front Oncol. April … for HER2-positive metastatic breast cancer: a systematic review …
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Study Links PAK5 to Poor Outcomes and Drug Resistance in HER2-Positive Breast Cancer
23 Apr 2025 17:13 GMT
… receptor-positive (HER2+) breast cancer (BC), according to … understand how PAK5 affects breast cancer, researchers measured its … both trastuzumab and lapatinib (Tykerb; GSK), another targeted … accumulation in HER2-positive breast cancer. Cell Death & …
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Neratinib Generates CNS Responses Across HER2+ Breast Cancer Brain Metastases Subgroups
10 Mar 2025 21:27 GMT
… treatments specifically targeting HER2-positive breast cancer brain metastases,” the authors explained … patients with no prior lapatinib (Tykerb) exposure, and cohort 3B ( … sequencing treatments for patients with breast cancer brain metastases,” the authors …
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Systemic Therapies Are Now Preferred in Some Patients With HER2+ Breast Cancer Brain Metastases
08 Mar 2025 19:13 GMT
… T-DM1, lapatinib (Tykerb) plus capecitabine, and … with HER2-positive metastatic breast cancer for brain metastases … HER2+ Breast Cancer. Presented at: 42nd Annual Miami Breast Cancer Conference. … HER2-positive metastatic breast cancer and brain metastases: …
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ARX788 Displays Activity in HER2+ Advanced Breast Cancer
05 Mar 2025 16:37 GMT
… ) benefit vs lapatinib (Tykerb) plus capecitabine for the … HER2-positive advanced breast cancer who experienced disease … or metastatic breast cancer or locally advanced breast cancer not amenable … HER2-positive advanced breast cancer. Signal Transduct Target …
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Tanshinlactone May Inhibit the Growth of ER+, HER2+, or EGFR-Mutated Cells in Breast Cancer
24 Feb 2025 19:58 GMT
… and EGFR-positive (EGFR+) breast cancer (BC). The data … cells. The anti-breast cancer effect happens when … tanshinlactone worked against breast cancer cells that resist (Tykerb; Novartis), a … Tanshinlactone triggers methuosis in breast cancer cells via NRF2 …
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Adjuvant regimen extends survival in early HER2-positive breast cancer
16 Jan 2025 11:04 GMT
… treatments for early breast cancer were administered either … HER2-positive early breast cancer who receive neoadjuvant … in HER2-positive metastatic breast cancer,” Geyer said. “ … Tykerb, Novartis] in patients with metastatic, HER2-positive breast cancer …
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The Evolution of ADCs in Breast Cancer: Challenges and Innovations
12 Dec 2024 08:02 GMT
… breast cancer (BC). At the 2024 San Antonio Breast Cancer … PFS compared with lapatinib (Tykerb; Novartis) plus capecitabine … advanced or metastatic breast cancer (EMILIA). ClinicalTrials. … (HER3) positive metastatic breast cancer. ClinicalTrials.gov Identifier: …
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Gupta Discusses T-DM1’s Role in HER2+ Breast Cancer Treatment
23 Oct 2024 02:10 GMT
… patients with HER2-positive breast cancer.
Ado-trastuzumab emtansine, … with HER2-positive early breast cancer and residual invasive … patients with difficult-to-treat breast cancers.
Transcription:
0:09 | … than capecitabine and lapatinib [Tykerb] as based on …
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Breast Cancer Screening and Treatment Update
18 Sep 2024 16:27 GMT
… for invasive breast cancer. The NCCN Breast Cancer Risk Reduction … metastatic breast cancer; and treatment of advanced breast cancer … decrease in breast cancers. Guidance on breast cancer screening in … November 2023.
28. Tykerb (lapatinib) product information. …